Courses
From Stanford Biomechanical Engineering Division
Undergraduate
ME 10N Form and Function of Animal Skeletons
Preference to freshmen. The biomechanics and mechanobiology of the musculoskeletal system in human beings and other vertebrates on the level of the whole organism, organ systems, tissues, and cell biology. Field trips to labs. Preference to freshmen; sophomores admitted if space available. Application required. 3 units (Carter, D)
Advanced Undergraduate and Beginning Graduate Courses
ME 280 Skeletal Development and Evolution
The mechanobiology of skeletal growth, adaptation, regeneration, and aging is considered from developmental and evolutionary perspectives. Emphasis is on the interactions between mechanical and chemical factors in the regulation of connective tissue biology. Prerequisites: 80, or Human Biology core, or Biological Sciences core. 3 units (Carter, D)
ME 281 Biomechanics of Movement
(Same as BIOE 281.) Experimental techniques to study human and animal movement including motion capture systems, EMG, force plates, medical imaging, and animation. The mechanical properties of muscle and tendon, and quantitative analysis of musculoskeletal geometry. Projects and demonstrations emphasize applications of mechanics in sports, orthopedics, and rehabilitation. 3 units (Delp, S)
ME 284A Cardiovascular Biomechanics
(Same as BIOE 284A.) Bioengineering principles applied to the cardiovascular system. Anatomy of human cardiovascular system, comparative anatomy, and allometric scaling principles. Cardiovascular molecular and cell biology. Overview of continuum mechanics. Form and function of blood, blood vessels, and the heart from an engineering perspective. Normal, diseased, and engineered replacement tissues. 3 units (Taylor, C)
ME 284B Cardiovascular Biomechanics
(Same as BIOE 284B.) Continuation of ME 284A. Integrative cardiovascular physiology, blood fluid mechanics, and transport in the microcirculation. Sensing, feedback, and control of the circulation. Overview of congenital and adult cardiovascular disease, diagnostic methods, and treatment strategies. Engineering principles to evaluate the performance of cardiovascular devices and the efficacy of treatment strategies. 3 units (Taylor, C)
ME 287 Soft Tissue Mechanics
Structure/function relationships and mechanical properties of soft tissues, including nonlinear elasticity, viscoelasticity, and poroelasticity. 3 units (Levenston, M)
ME 289 Biomechanical Engineering Research Seminar
BME research conducted at Stanford for incoming students. Graduate students and postdoctoral fellows present research emphasizing motivation of research questions, project design, methods, and preliminary results. 1 unit (TBA)
ME 294 Medical Device Design
In collaboration with the School of Medicine. Introduction to medical device design for undergraduate and graduate engineering students. Design and prototyping. Labs; medical device environments including hands on device testing; and field trips to operating rooms and local device companies. Limited enrollment. Prerequisite: 203. 3 units (Milroy, J; Doshi, R)
Graduate
ME 337 Mechanics of Growth
Introdution to continuum theory and numerical solutions or biomechanical problems. Kinematics of finite growth. Balance equations in open system thermodynamics. Constitutive equations for biological tissues. Enhanced finite element models in biomechanics. Analytical solutions for simple model problems. Numerical solutions for more advanced problems such as: bone remodeling; wound healing; muscle regeneration; tumor growth; atherosclerosis; in-stent restenosis; and tissue engineering. 3 units (Kuhl, E)
ME 339 Mechanics of the Cell
Kinematical description of basic structural elements used to model parts of the cell: rods, ropes, membranes, and shells. Formulation of constitutive equations: nonlinear elasticity and entropic contributions. Elasticity of polymeric networks. Applications to model basic filaments of the cytoskeleton: actin, microtubules, intermediate filaments, and complete networks. Applications to biological membranes. 3 units (Kuhl, E)
ME 341 Biomechanics of Hearing, Speech, and Balance
Theory and practice of building mathematical models to understand physical phenomena; integration of imaging, physiology, and biomechanics. Journal club style discussions of research literature, examples from hearing science, speech production, and the vestibular system. Dualisms in modeling include: general principles versus detailed models; analytic versus computational models; forward versus inverse approaches; and the interplay between theory and experiments. 3 units (Puria, S)
ME 374A Biodesign Innovation: Needs Finding and Concept Creation
(Same as BIOE 374A, OIT 384, MED 272A.) Two quarter sequence. Strategies for interpreting clinical needs, researching literature, and searching patents. Clinical and scientific literature review, techniques of intellectual property analysis and feasibility, basic prototyping, and market assessment. Student entrepreneurial teams create, analyze, and screen medical technology ideas, and select projects for development. 3-4 units (Yock, P; Zenios, S; Brinton; Milroy, C)
ME 374B Biodesign Innovation: Concept Development and Implementation
(Same as BIOE 374B, OIT 385, MED 272B.) Two quarter sequence. Concept development and implementation. Early factors for success; how to prototype inventions and refine intellectual property. Lectures, guest medical pioneers, and entrepreneurs about strategic planning, ethical considerations, new venture management, and financing and licensing strategies. Cash requirements; regulatory (FDA), reimbursement, clinical, and legal strategies, and business or research plans. 3-4 units (Yock, P; Zenios, S; Brinton; Milroy, C)
ME 381 Orthopaedic Bioengineering
Engineering approaches applied to the musculoskeletal system in the context of surgical and medical care. Fundamental anatomy and physiology. Material and structural characteristics of hard and soft connective tissues and organ systems, and the role of mechanics in normal development and pathogenesis. Engineering methods used in the evaluation and planning of orthopaedic procedures, surgery, and devices. 3 units (Carter, D)
ME 382A Medical Device Design
Real world problems and challenges of biomedical device design and evaluation. Students engage in industry sponsored projects resulting in new designs, physical prototypes, design analyses, computational models, and experimental tests, gaining experience in: the formation of design teams; interdisciplinary communication skills; regulatory issues; biological, anatomical, and physiological considerations; testing standards for medical devices; and intellectual property. 4 units (Andriacchi, T)
ME 382B Medical Device Design
Continuation of industry sponsored projects from 382A. With the assistance of faculty and expert consultants, students finalize product designs or complete detailed design evaluations of new medical products. Bioethics issues and strtegies for funding new medical ventures. 4 units (Andriacchi, T)
ME 385 Tissue Engineering Lab
Hands-on experience in the fabrication of living engineered tissues. Techniques include sterile technique, culture of mammalian cells, creation of cell-seeded scaffolds, and the effects of mechanical loading on the metabolism of living engineered tissues. Theory, background, and practical demonstration for each technique. Lab. 1-2 units (TBA)
ME 398 Biomechanical Research Symposium
Guest speakers present contemporary research on experimental and theoretical aspects of biomechanical engineering and bioengineering. May be repeated for credit. 1 unit (Levenston, M)
Advanced Graduate
ME 484 Computational Methods in Cardiovascular Bioengineering
(Same as BIOE 484.) Lumped parameter, one-dimensional nonlinear and linear wave propagation, and three-dimensional modeling techniques applied to simulate blood flow in the cardiovascular system and evaluate the performance of cardiovascular devices. Construction of anatomic models and extraction of physiologic quantities from medical imaging data. Problems in blood flow within the context of disease research, device design, and surgical planning. 3 units (Taylor, C)
ME 485. Modeling and Simulation of Human Movement
(Same as BIOE 485.) Direct experience with the computational tools used to create simulations of human movement. Lecture/labs on animation of movement; kinematic models of joints; forward dynamic simulation; computational models of muscles, tendons, and ligaments; creation of models from medical images; control of dynamic simulations; collision detection and contact models. Prerequisite: 281, 331A,B, or equivalent. 3 units (Delp, S)
